Blue Light Cystoscopy vs White Light Cystoscopy for NMIBC Bladder Cancer

Blue light cystoscopy (BLC™) improves NMIBC detection and treatment versus White Light Cystoscopy (WLC) alone.

Cystoscopy, considered the gold standard diagnostic tool for bladder cancer, lets the doctor inspect the bladder lining very closely for signs of any abnormal growths or suspicious areas.

Standard white light cystoscopy involves a cystoscope with a lens and a white light for visualizing suspicious lesions. Once lesions are identified, the urologists can surgically remove cancerous tissues, through a procedure called a transurethral resection of the bladder tumor (TURBT). However, there is a high risk of missing tumors, especially the flat and aggressive carcinoma in situ (CIS) lesions. Enhanced technologies for better detection have been developed.

Blue Light Cystoscopy (BLC™) with Hexvix®/Cysview® is a technology that significantly improves the detection of non-muscle invasive bladder cancer compared to traditional white light cystoscopy alone. Studies show that 25%-30% more patients with bladder cancer are detected – patients who would have been missed under standard white light and sent home as cancer-free. (Source: Burger et al, Eur Urol 2013)

This improved detection is the result of the drug, Hexaminolevulinate, being selectively absorbed by cancer cells and causing them to glow bright pink under blue light illumination, highlighting any tumors that may have not been seen using white light alone.

This improved detection is the result of the drug, Hexaminolevulinate, being selectively absorbed by cancer cells and causing them to glow bright pink under blue light illumination, highlighting any tumors that may have not been seen using white light alone.

 

Blue light cystoscopy vs traditional cystoscopy

Blue light cystoscopy improves detection of cancer cells.

When the tumors are detected, they can be accurately diagnosed and completely removed. Correct diagnosis results in more appropriate follow-up, treatment and disease management. Better detection and more complete removal of the tumors have been shown to reduce the risk of recurrence and progression. This will lead to better patient outcomes, as well as reduced burden both for patients and the health care system.

Illustration showing the need for follow up treatments

The diagram above shows the typical NMIBC patient journey

The patient experiences symptoms such as e.g. blood in the urine and consults their family doctor, who examines them. If blood in the urine is confirmed, the patient is referred to a urologist for a cystoscopy. This first diagnostic cystoscopy is performed in an office/clinic with a thin, flexible cystoscope, under local anesthesia. This is typically a 15-minute procedure. If suspected cancerous areas are identified, the patient will be referred to a more thorough examination in the operating room and under general anesthesia. A thicker, so-called rigid cystoscope is used, biopsies of suspicious areas are taken, and tumor tissue removed (TURBT surgery). The results of the biopsies will define the patient's risk group, which in turn will decide treatment and follow-up regimes.

BLC™ with Hexvix® / Cysview® is indicated for use both during the surgical procedure with rigid cystoscopes under general anesthesia and for the follow-up cystoscopies with the thin, flexible scopes in the clinic/office.

Hexvix® / Cysview® is selectively taken up by cancer cells, making them glow bright pink/red when inspected using a blue light-enabled cystoscope. Making the tumors visible allows for early and better detection and more complete removal of tumors, leading to better patient management, including reduced recurrence and progression.

Learn more Photocure's bladder cancer products Hexvix® / Cysview®

Photocure is the innovator and developer of blue light cystoscopy with Hexvix® / Cysview® (Hexaminolevulinate). We maintain the largest registry of bladder cancer patients in the US which contributes to our evidence base and continuous collection of new data and experience. We support the largest community of bladder cancer patients and caregivers, which ensures that we regularly receive ideas and input that drives further research and innovation.

See the latest developments in Blue Light Cystoscopy from Photocure